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The pharmaceutical packaging market should pay attention to the compatibility of medicines and packaging materials – Maypak

An investigation from the State Food and Drug Administration shows that the overall technical level of my country’s pharmaceutical packaging materials industry is not high, the grade is low, and far behind developed countries, the quality of packaging materials is not high, and the contribution rate to the pharmaceutical industry is relatively low. low.

In order to standardize the development of pharmaceutical packaging, my country has gradually introduced a standardized and standard system for the pharmaceutical industry, and policy supports the development of pharmaceutical packaging. At present, the development trend of the pharmaceutical packaging market is: white packaging technology has been widely used, mechanical technology packaging has become an upstart, and the safety of pharmaceutical packaging has received increasing attention. Chinese pharmaceutical packaging companies must first abide by the relevant national policies and regulations, pay attention to the compatibility of drugs and packaging materials, and ensure the stability of the packaging materials to the drugs during the storage period and the safety during use.

In the selection of new materials, the material of the packaged pills is changed from paper bags, paper-plastic bags to aluminum-plastic bags, pearlescent film bags, etc.; high-density polyethylene plastic bottles, polyester plastic bottles, etc. replace glass bottles; traditional Chinese medicine Tai Mi Pills The packaging form of PVC heat-sealing will also be replaced by aluminum-plastic blister packaging. The process of using bakelite wax to seal glass bottles has been completely eliminated, and aluminum foil and other materials with better sealing and higher production efficiency are used for sealing.

In the choice of various dosage form packaging methods, Western medicine tablets and capsules, powders and granules of Chinese patent medicines, etc. will mainly use blister packaging and aluminum-plastic blister packaging. The most commonly used medical blister packaging materials are PVC (polyvinyl chloride) and PVDC (polyvinylidene chloride).

PVC has good compatibility, easy to form and seal, low price, transparency, barrier properties and mechanical strength can basically meet the requirements of pharmaceutical packaging, but its ability to block water vapor and thermal stability is poor, and it has high requirements for moisture resistance. For medicines, PVC is not satisfactory. PVDC has high density, regular structure, high crystallinity and transparency, and good weather resistance.

PVDC film is currently the best film with the best barrier properties. The PVDC film with the same thickness has 1500 times that of PE and 100 times that of PP and PET, and its barrier performance to water vapor is also higher than that of PVC. It is an ideal material for blister packaging. Multi-layer composite hard film made of PVDC and other film materials composite or coating, such as PVC/PVDC, BOPP/PVDC, PVC/PVDC/PE, PVDC/OPP/PE, etc., oxygen permeability, moisture permeability and moisture resistance The performance and barrier properties are significantly higher than that of a single-material film, combining the advantages of multiple materials into one, providing a high-quality and low-cost choice for blister packaging.

Another kind of blister packaging material is vacuum aluminized film, which is a kind of flexible packaging film in which aluminum is sprayed onto various base films under high vacuum. The materials widely used in the packaging of powders, granules and powders of Chinese patent medicines include PETP, CPP, FT, OPP, PE and other vacuum aluminized films. Among them, PETP, CPP, and PE are the most widely used.

In addition to the characteristics of a plastic base film, vacuum aluminized film packaging also has beautiful decoration and good barrier properties. Especially after all kinds of plastic substrates are plated with aluminum, their light transmittance, oxygen permeability, water permeability, and water vapor permeability will be reduced to one tens or even one percent, which can well prevent the mold from becoming moldy, Moisture absorption ensures the safety of consumers’ medication